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Mesenchymal stem cells (MSCs), as distinct from the embryonic type, may be the key to healing diabetic foot ulcers. These stem cells can differentiate into various cell types. As a fetus develops, MSCs help drive its rapid initial growth; by the time we reach our teens, however, MSCs are mostly found in bone marrow. When wounded or burned, our skin craves MSCs, which it harbored when first growing. In fact, recent studies show that surgically moving these cells from bone marrow onto hard-to-heal wounds accelerates healing. In contrast to surgically removing MSCs from bone marrow—a painful, time consuming and expensive process—a new topical drug, the novel angiotensin analog DSC127, appears to activate the mesenchymal stem cells in a patient’s body. “It appears that DSC127 directs MSCs to the injury site, mobilizing them to help repair wounded or burned skin, accelerate healing and reduce scar formation,” said Edward J. Quilty, Chairman & CEO of Derma Sciences Inc. Based in Princeton, New Jersey, Derma Sciences develops, manufactures, and markets innovative wound care products. “DSC127,” Quilty observed, “thus works as a catalyst for a stem cell treatment that is free of both the ethical controversies surrounding the medical use of fertilized embryos as well as potentially painful surgical interventions.” Currently in a 75-patient Phase II diabetic foot ulcer clinical trial being conducted at some of the nation’s top institutions, the drug is being considered for additional indications including venous leg ulcers, arterial ulcers, pressure ulcers, thermal and chemical wounds, and scar prevention. Pre-clinical animal studies have demonstrated the efficacy of the compound in accelerating healing and reducing scar formation. If DSC127 is approved for market, patients with diabetic foot ulcers may find a solution already exists within their own bodies. For more information, visit www.dermasciences.com. Subscribe to our FREE Ezine and be eligible for Health News, discounted products/services and coupons related to your Health. We publish 24/7. HealthNewsDigest.com We videotape Press Conferences, produce SMT's, VNR's, B-rolls, PSA's, - all with distribution: HealthyTelevisionProductions Top of Page
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