Yerkes-based research is critical to determining why some species
are more susceptible to infectious diseases
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(HealthNewsDigest.com) – Researchers at the Yerkes National Primate Research Center, Emory University, have discovered a possible new mechanism by which sooty mangabeys, a natural host of simian immunodeficiency virus (SIV), avoid developing AIDS despite having very high viral loads. The study, available in the current issue of Blood, shows sooty mangabeys are able to maintain levels of CD4+ T cells by regenerating more rapidly their pool of naïve CD4+ T cells. CD4+ T cells are a type of white blood cell key to maintaining the immune system and are important because they allow the immune system to respond to newly encountered microbes. This finding may help explain why SIV and HIV lead to AIDS in other nonhuman primates and humans, respectively, but not in the sooty mangabey.
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